Klappentext

The life expectancy of liver cirrhosis patients drastically worsens with decompensation. In this work, a clinical score was developed to identify patients at high risk for decompensation enabling targeted treatment. Furthermore, to facilitate treatment and drug development for liver cirrhosis patients, a PBPK framework for liver cirrhosis was developed. The presented work provides two tools for treatment optimization of liver cirrhosis patients potentially improving patient health in the future.