Kurzbeschreibung

Discussing the diagnosis, therapy and prognosis in one self-contained text, this volume presents a broad view of the CNS tumor and brain tumor imaging fields of research in Europe. The genetics of malignant brain tumors and gene amplification are explained, as well as standard and new imaging modalities.

Inhaltsangabe

1. The World Health Organization Classification of the Central Nervous System Tumors: an Update Using Imaging; Shiori Amemiya
Introduction
Astrocytic Tumors
Pilomyxoid astrocytoma
Neuronal and Mixed Neuronal-Glial Tumors
Papillary Glioneuronal Tumor
Extraventricular Neurocytoma
Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle
Other Neuroepithelial Tumors
Angiocentric Glioma
Tumors of the Pineal Region
Papillary Tumor of the Pineal Region
Embryonal Tumors
Medulloblastoma with Extensive Nodularity
Anaplastic Medulloblastoma
References
2. Brain Tumor Imaging: European Association of Nuclear Medicine Procedure Guidelines; Thierry Vander Borght, Susanne Asenbaum, Peter Bartenstein, Christer Halldin, Ozlem Kapucu, Koen Van Laere, Andrea Varrone, and Klaus Tatsch
Introduction
Background Information and Definitions
Common Indications
Indications
Detection of Viable Tumor Tissue
Tumor Delineation
Selecting the Best Biopsy Site
Noninvasive Tumor Grading
Therapy Planning
Tumor Response
Contraindications (relative)
Procedure
Patient Preparation
Prearrival
Preinjection
Information Pertinent to Performance of the Procedure
Precautions and Conscious Sedation Radiopharmaceutical
Radiopharmaceutical
Recommended Dosage
Radiation Dosimetry
Radiation Dosimetry of Brain Transmission Scans
Data Acquisition
Time Delay from Injection to Beginning of Data Acquisition
Set-up for Data Acquisition
Image Processing
PET Reconstruction
SPECT Reconstruction
Reformatting of PET and SPECT Images
Comparative Evaluation
Interpretation Criteria
Visual Interpretation
Quantification
Reporting
General
Body of the Report
Interpretation and Conclusion
Issues Requiring Further Clarification
References
3. Assessment of Heterogeneity in Malignant Brain Tumors; Timothy E. Van Meter, Gary Tye, Catherine Dumur, and William C. Broaddus
Introduction
The problem of Heterogeneity and Its Clinical Significance
Previous Studies Assessing Molecular Heterogeneity of Tumors
Use of Stereotactic Neuroimaging Systems for Tumor Sampling
Methodology
Description of Method
MRI-Guided Stereotactic Biopsy
Integrated Histopathological Scoring
Use of Genomics Technologies for Regional Molecular Profiling
Results
Histopathological Considerations
Assessing Quality of Biopsy Extracts
Genomic Assessment of Regional Tumor Phenotype
Validation Studies
Discussion
Utility of Stereotactic Biopsy for Tumor Characterization
Future Technical Applications
Clinical Impact of Improved Tumor Characterization
References
4. Diagnosing and Grading of Brain Tumors: Immunohistochemistry; Hidehiro Takei and Suzanne Z. Powell
Introduction
Immunohistochemical Markers for Diagnosis and Differential Diagnosis of Brain Tumors
Immunohistochemical Markers Routinely Used In Diagnostic Neuro-Oncology
Practice
New Immunohistochemical Markers Applicable to Brain Tumor Diagnosis
Useful Immunohistochemical Markers for Differential Diagnosis of Brain Tumors
Immunohistochemistry as a Useful Adjunct in Grading of Brain Tumors: Ki-67 and Phospho-Histon H3
Immunohistochemical and Analytical Methods
References
5. Malignant Brain Tumors: Roles of Aquaporins; Jerome Badaut and Jean-Francois Brunet
Introduction
Aquaporin Expression in Normal Brain and its Function
Aquaporin Distribution and its Potential Role
Aquaporin Astrocyte Endfeet Marker in Brain Water Homeostasis
Involvement of Aquaporin 9 Expression in Brain Energy Metabolism
Aquaporin Distribution in Tumors: Role in Prognosis and Treatment
Aquaporin in tumors: Water Homeostasis or Cell Migration?
Aquaporin 4 in Tumors: Biomarker for Tumor Classification
AQP9 in Brain Tumors: New Findings
References
6. Brain Metastases: Gene Amplification Using Quantitative Real-time Polymerase Chain Reaction Analysis; Carmen Franco-Hernandez, Miguel Torres-Martin, Victor Martinez-Glez, Carolina Pena-Granero, Javier S. Castresana, Cacilda Casartelli and Juan A. Rey
Introduction
Objectives

Klappentext

This eighth volume in the series Methods of Cancer Diagnosis, Therapy, and Prognosis discusses in detail the classification of the CNS tumors as well as brain tumor imaging. Scientists and Clinicians have contributed state of the art chapters on their respective areas of expertise, providing the reader a whole field view of the CNS tumors and brain tumor imaging in Europe.

This fully illustrated volume:
Explains the genetics of malignant brain tumors and gene amplification using quantitative-PCR;
Presents a large number of standard and new imaging modalities, including magnetic resonance imaging, functional magnetic resonance imaging, diffusion tensor imaging, amide proton transfer imaging, positron emission tomography, single photon emission computed tomography, magnetic resonance single voxel spectroscopy and intraoperative ultrasound imaging, for staging and diagnosing various primary and secondary brain cancers;
Explains the usefulness of imaging methods for planning and monitoring (assessment) therapy for cancers;
Discusses diagnosis and treatment of primary CNS lymphomas, CNS atypical teratoid / rhabdoid and CNS Rosai-Dorfman disease;
Includes the subject of translational medicine.

Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.