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This volume contains invited and accepted contributions presented at the Nineteenth International Conference on Membrane Computing (CMC19, http://cmc19.uni-jena. de) which took place in Dresden (Germany) from 4 to 7 September 2018, organised by the Friedrich Schiller University Jena (Germany) together with the Jena Centre for Bioinformatics (JCB) under the auspices of the International Membrane Computing Society (IMCS). We appreciate the hospitality of the NH Hotel and Conference Centre Dresden-Neustadt. Taking place for the second time in Germany and for the first time in Dresden, CMC19 is pleased to continue the fruitful tradition of 18 previous events of the International Workshop and Conference on Membrane Computing (WMC/CMC) enriched by some new ideas and inspirations emphasising multidisciplinarity and innovative capacity and inspired by the idea of bringing together researchers working in membrane computing or related areas in a friendly atmosphere enhancing communication and cooperation.