Esmond J. Sanders: The Cell Surface in Embryogenesis and Carcinogenesis: Common Mechanisms, Gebunden

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PREFACE. MAKING CONNECTIONS. THE CONTROL OF CELL MOVEMENT IN EARLY EMBYRONIC DEVELOPMENT. GASTRULATION IN AVIAN EMBRYOS. Contact Inhibition of Locomotion. Extracellular Matrix. Contact Guidance. Chemotaxis and Haptotaxis. Gastrulation as an Example of Embryonic Cell Invasion. MESODERM MORPHOGENESIS. Sclerotome Cell Migration. Expansion of the Area Vasculosa Mesoderm. MAMMALIAN GASTRULATION. TERATOCARCINOMAS. AMPHIBIAN GASTRULATION. PRIMORDIAL GERM CELL MIGRATION. Amphibian PGCs. Avian PGCs. Mammalian PGCs. NEURAL CREST CELL MIGRATION. Pathways of Migration. Factors Affecting the Behavior of the Migrating Cells. Extracellular Matrix. THREE DIMENSIONAL COLLAGEN MATRICES. Mesoderm and Neural Crest Cells. Cardiac Cushion Cells. OBSERVATIONS ON CELLS IN LIVING EMBRYOS. Sea Urchin Primary Mesenchyme Cells. Teleost Deep Blastomeres. PASSIVE CELL MOVEMENTS. BASEMENT MEMBRANES IN EMBRYOGENESIS. GENERAL ULTRASTRUCTURE. MOLECULAR CONSTITUENTS. Proteoglycans. Type IV Collagen. Other Collage ns. Laminin. Fibronectin. Other Glycoproteins. COMPONENT ORGANIZATION. SYNTHESIS AND TURNOVER. SOME GENERAL ROLES FOR BASEMENT MEMBRANES IN DEVELOPMENT. A Substratum for Morphogenetic Migration. Maintenance of Epithelial Polarity and Stability. Regulation of Epithelial Folding Morphogenesis. Mediation of Epithelial-Mesenchymal Inductive Interactions. BASEMENT MEMBRANES IN EARLY DEVELOPMENT. Avian Gastrulation. Neural Crest Cells. Primordial Germ Cells. Early Mammalian (Rodent) Development. Implantation. Teratocarcinoma Basement Membranes. DEGRADATIVE ENZYMES IN DEVELOPMENT. Hyaluronidase. Collagenase. Plasminogen Activators. EPITHELIAL-MESENCHYMAL INDUCTIVE INTERACTIONS. Kidney Development. Limb Bud Development. Chondrogenesis and Osetogenesis. Tooth Development. Morphogenesis of Skin. CELL INVASIVENESS IN CANCER. NORMAL CELLS vs. TUMOR CELLS. Cell Proliferation. Cell Movement. MALIGNANT TUMORIGENICITY. Breakout and Primary Invasion. Intravasation and Dissemination. Arrest and E xtravasation. Secondary Invasion and Proliferation. INVASIVENESS. In Situ Studies of Invasiveness. Model Systems for Invasion Studies. Malignant Cells Transplanted into Embryos. Directionality of Invasiveness. TUMOR CELL INTERACTIONS IN VITRO. Contact Inhibition of Locomotion. ROLE OF THE EXTRACELLULAR MATRIX. Glycosaminoglycans and Proteoglycans. Glycoproteins. MATRIX AND BASEMENT MEMBRANE DEGRADATION IN INVASION. Proteoglycans and Fibronectin. Collagen. Basement Membranes. MATTERS OF THE CELL SURFACE. GLYCOPROTEINS AND GLYCOLIPIDS. Glycoproteins. Glycolipids. Cell Surface Charge. MEMBRANE RECEPTORS FOR THE EXTRACELLULAR MATRIX. CELL SURFACES IN DEVELOPMENT. The Early Avian Embryo-Gastrulation and Somitogenesis. The Early Mammalian Embryo. The Early Amphibian Embryo. Primordial Germ Cells. Sea Urchin Development. SURFACES OF CANCER CELLS. Cell Surface Glycoconjugates. Functional Surface Adhesion Molecules. CELL-TO-CELL AND CELL-TO-SUBSTRATUM CONTACT. INTERCELLULAR CONTACTS. Des mosomes. Adhaerens